Neurology/Research Methodology

Neurology / Research Methodology

The Optalert BlinQ^TM system for neurologists and researchers

Using Infrared reflectance blepharometry (via scientific glasses), and validation against the patented Johns Drowsiness Scale (JDS), measurements of eyelid movements are accurately quantified.

Tailored solutions can be conducted in a controlled or naturalistic environment depending on the nature of research.

Optalert’s data scientists can provide expert ocular metric data analysis including:

• Raw ocular metric event detection
• Exploratory data analysis

Biomarkers for neurological disorders

For neurologists and researchers interested in exploring the use of blepharometry to investigate biomarkers with their patients,

Optalert provides:

1) Recording Apparatus

Optalert has recording equipment that can be used in a variety of settings:

1. Controlled environment
   For controlled environments, Optalert’s computer-based software allows for simultaneous recordings of eyelid movements and performance metrics using Optalert’s own computerised vigilance task, the ‘Johns Test of Vigilance’.
2. Naturalistic environment
   For environments that cannot be controlled and where data needs to be collected away from a laboratory, Optalert has a portable data logger and wireless glasses that provide portability of the product and maintain ease of movement for the patient.For optimal results Optalert recommends recording in a controlled environment where possible, but we understand that this may not always be practical and can help tailor a solution to suit your research requirements.

2) Expert data analysis

Expert data analysis of the eye and eyelid movements includes:

1. Raw event detection
   Optalert has established methods for detecting even the slightest change in position of the eye and eyelid. These events are quickly detected and their amplitude, duration and velocities calculated.
2. Pre-existing identification/classification using patent protected algorithms
   Pre-existing identification and classification algorithms determine whether they are from the closing, closed or re-opening phase of blinks, are saccadic eye movements or artefact. Some specific examples of important variables include:- Amplitude-velocity ratio (AVR): The amplitude-velocity ratio of saccades and blinks is very tightly controlled and specific to eyelids. This varies greatly between alert and drowsy states within individuals2.- Ocular quiescence: May be significant when related to evidence of other conditions such as epilepsy (absence seizures; staring blankly) and depression (losing awareness and withdrawing socially)- Duration of eyelid closures
3. Exploratory data analysis
   Optalert’s skilled team of data scientists are able to help researchers synchronise eye and eyelid movement data with other relevant data to identify changes in state or disorder.

Optalert invites neurological researchers to discuss their research requirements with us today. info@optalert.com

References:
1. Tucker AJ, Johns MW, The Duration Of Eyelid Movements During Blinks: Changes With Drowsiness. SLEEP, 2005, Vol 28,
Abstract Supplement A122
2. Johns MW, Tucker AJ, The Amplitude-Velocity Ratios Of Eyelid Movements During Blinks: Changes With Drowsiness.
SLEEP, 2005, Volume 28, Abstract Supplement A122