Biomarker Research

Biomarker Research

Research has found that eyelid movements are very tightly physiologically controlled when in the alert state, but begin to deviate as a person changes state – for example, the duration of a blink increases with drowsiness1. As a person moves into the drowsy state and their level of impairment increases, these same movements begin to vary significantly and in some instances up to 200%.

After two decades of scientific research, Optalert has developed a scientifically proven and independently validated patented algorithm to detect drowsiness. Optalert’s research shows that blepharometry, or measuring the change in eyelid movements, shows an early prediction of when a person changes their state of awareness from alert-wakefulness to drowsy. Blepharometry also has the potential to be useful in detecting other state changes in various neurological disorders.[/vc_column_text][vc_column_text]


Optalert is currently working with research organizations to investigate the prediction of epileptic seizures. The possibility of detecting seizures early or other neurological changes, could enable accurate screening, the ability to monitor disease progression and assess response to treatments as they become available.

Other potential opportunities:

  • Patient Intervention & Empowerment
    • Advance warning of an altered state e.g. Seizures, Hypoglycemia
    • Objective assessment and management of a disorder e.g. Depression
  • Patient Recovery,
    • Enabling comparison of healthy baseline vs new condition
      e.g. TBI (Concussion)